Nurse Support / Resources

Injection Video

The LUPRON DEPOT-PED injection video presents the 9 steps in the injection process and provides answers to frequently asked questions.

Z-Track Injection Technique

The Z-track intramuscular (IM) injection technique is named for the zigzag track that the needle traverses to help deliver and seal the medication into the muscle.1

This technique is a recommended method for administering an IM medication because it helps reduce the leakage of the medication through the subcutaneous tissue so the patient receives the full dose of medication.2

The 3 Simple Steps

Step 1: Before the injection

Pull the skin adjacent to the injection site downward or laterally by using your non-dominant hand to displace the tissue by about 1 inch. This helps progressively shift tissue layers above the muscle to the side.2

Step 2: During the injection

With a smooth, steady motion, pierce the skin at a 90-degree angle to the injection site.2

Step 3: After the injection

  1. While slowly releasing the skin back to its original position, withdraw the needle with a smooth, steady motion.2
  2. Do NOT massage the injection site, because this may cause the medication to enter the subcutaneous tissue or cause irritation2

Note: The dotted lines illustrate the zigzag needle path after administration

For reconstitution and administration instructions, please refer to the LUPRON DEPOT-PED full Prescribing Information

Learn more about the features of the LUPRON DEPOT-PED syringe


Nurse Training

Your patients have access to live nurse phone support throughout therapy.

Parents or caregivers can talk to a registered nurse about CPP or LUPRON DEPOT-PED therapy at no cost.

Distraction Techniques

Distraction techniques may help reduce anxiety for children being administered injections. Effective distraction techniques help focus the child’s thoughts away from the shot and onto something else.3,4

Distraction techniques can be provided by the parent, child, or healthcare provider. Common distraction techniques include3,4:

Playing with toys Listening to music
Telling stories Singing
Watching videos Counting
Reading books Talking about something else (e.g. favorite movie, etc.)
Joking Having the child cough vigorously as the needle comes into contact with the skin5

Please contact your LUPRON DEPOT-PED Sales Representative for additional distraction techniques


Parent demeanor also plays a significant role in helping reduce the child’s anxiety.4

  • Humor, non-procedural talk, and suggestions on how to cope are related to decreases in child distress
  • Reassurance and apologies are related to increases in child distress


Multiple resources are available to your patients and parents to understand CPP and stay on track with treatment

A step-by-step brochure that discusses CPP and its treatment

Support PLUS is your source for streamlined support

A smartphone app is available at no additional cost that helps parents and caregivers manage the child’s experience with CPP

References: 1. Antipuesto DJ. Z-Track Method. Nursing Crib website. Available at: nursing-notes-reviewer/fundamentals-of-nursing/z-track-method. Accessed June 6, 2016. 2. Nursing Center website. Z-Track Injections. Available at: Accessed June 23, 2016. 3. Taddio A, Appleton M, Bortolussi R, et al. Reducing the pain of childhood vaccination: an evidence-based practice guideline. CMAJ. 2010;182(18):E843-855. 4. Capital Health. Help eliminate pain in kids: Clinical practice guideline for pain management during childhood immunizations. Available at: 127/documents/pain-management-during-childhood-immunizations.pdf. Accessed August 24, 2016. 5. Dobson R. Coughing can reduce pain of injection, study shows. BMJ. 2004;328(7437):424.